By Errol C Friedberg
With a Foreword by means of Sydney Brenner (Nobel laureate in body structure or medication, 2002)
This biography information the lifetime of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's lifestyles from beginning, in 1926, to the current, with targeted emphasis on his huge, immense clinical contributions, together with being the 1st to boost expertise that ended in gene cloning technological know-how. In 1980, Berg acquired a Nobel Prize in chemistry for this work.
In addition to his contributions within the learn laboratory, Berg orchestrated and oversaw a historical assembly at Asilomar, California that founded on a threatening controversy surrounding the conception by way of a number of the damaging capability of recombinant DNA expertise. This assembly did a lot to stop this controversy and to install position the rules of recombinant DNA paintings, therefore placing fears to rest.
The recombinant DNA controversy used to be a old final result of the invention of gene cloning. significantly, it represented a paramount instance of medical foresight and due diligence through the clinical group, instead of via regulatory entities within the usa and lots of different nations. the last word attractiveness of gene/DNA cloning resulted in a brand new period of contemporary biology that prospers to the present.
This e-book is aimed basically at scientists and people in education. The ebook strives to easily offer info for the final reader, yet isn't in particular adapted for a normal analyzing audience.
While many books hide the recombinant DNA controversy, none have satisfactorily addressed this ancient interval and are usually contradictory in regards to the many who is, where's, and why's concerned. also, the nice majority of those have been written by way of non-scientists. This biography of Paul Berg offers entry to various archived letters and records at Stanford college now not formerly addressed, and to the chronology of occasions as recalled and documented by means of him, in addition to different key personalities, a lot of whom have been interviewed.
- Part I:
- Growing Up in Brooklyn
- The crucial Paul Berg
- College — and global battle II
- Western Reserve University
- Part II:
- Washington collage, St. Louis
- Discovering move RNA
- Stanford college — and Its Refurbished division of Biochemistry
- Transcription and Translation: New Directions
- Part III:
- Making Recombinant DNA — the 1st Faltering Steps
- Making Recombinant DNA — a tremendous Breakthrough
- EcoRI limit Endonuclease — an incredible Breakthrough
- “Coincidence is the note We Use after we cannot See the Levers and Pulleys”
- Yet one other Stanford Contribution
- Part IV:
- An old assembly in Hawaii
- The Recombinant DNA Controversy
- A Momentous Gordon learn Conference
- Making Recombinant Molecules with Frog DNA
- The Controversy Heats Up
- Asilomar II
- The Dissenters: a special aspect of View
- The Aftermath
- Legislative and Revisionist demanding situations to Recombinant DNA
- Asilomar II — classes Learned
- Part V:
- The Nobel Prize in Chemistry
- Commercializing the Technology
- Life is going on
- The “Retirement” Years
- Public coverage concerns — and different Interests
- Personal Challenges
Readership: Researchers, graduate scholars, undergraduates in existence sciences, medication and chemistry and lay public.
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Extra resources for A Biography of Paul Berg:The Recombinant DNA Controversy Revisited
A Biography of Paul Berg:The Recombinant DNA Controversy Revisited by Errol C Friedberg